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The asymmetric synthesis of (2 S ,3 R )-capreomycidine
- Source :
- Tetrahedron Letters. 42:3529-3532
- Publication Year :
- 2001
- Publisher :
- Elsevier BV, 2001.
-
Abstract
- An improved asymmetric synthesis of the guanidine-containing amino acid (2 S ,3 R )-capreomycidine has been achieved in seven steps and 28% overall yield. The key synthetic step involved a Mannich-type reaction between a chiral glycine aluminum enolate and the benzyl-imine of 3- tert -butyldimethylsiloxy-propionaldehyde.
Details
- ISSN :
- 00404039
- Volume :
- 42
- Database :
- OpenAIRE
- Journal :
- Tetrahedron Letters
- Accession number :
- edsair.doi...........896331ffab5229c5ac58d183f5542310
- Full Text :
- https://doi.org/10.1016/s0040-4039(01)00487-7