IC‐P‐112: Multicenter stability, diagnostic accuracy and regional specificity of cholinergic forebrain atrophy in Alzheimer's disease: A European Diffusion Tensor Imaging Study in Dementia (EDSD)

related to the non-stationary nature of the connectivity within ICNs. Methods: We performed a large (n 1⁄4 892) high-dimensional independent component analysis decomposition of TF-fMRI data on cognitively normal (CN) subjects drawn from theMayo Clinic Study of Aging. This was used to atlas the brain into 68 regions, categorized based on network of origin, anatomical locations, and a functional meta-analysis. These regions were used to construct dynamic graphical representations of the brain within a sliding timewindow.We calculated dwell time in particular network configurations in 892 CN and 28 AD subjects. Results: The 80,280 graphs displayed a highly modular architecture relative to the null model (Q* 1⁄4 0.55 +/-0.06 vs. null Q*1⁄4 0.16 +/0.01, P