Back to Search
Start Over
Beyond antibodies ? lessons from bacterial ?immunity?
- Source :
- Microbiology Australia. 27:80
- Publication Year :
- 2006
- Publisher :
- CSIRO Publishing, 2006.
-
Abstract
- Isolation and production of highly specific protein-based binding molecules are crucial to the ever expanding diagnostics, therapeutics and protein array fields. Traditionally, such reagents have been sourced from vertebrate immune systems, where antibodies have evolved over millennia into highly effective molecules of immune surveillance capable of targeting a huge range of targets in response to infection and disease. Now, a growing number of alternative protein scaffolds are being investigated as specific binding molecules incorporating a diverse and powerful range of binding and recognition interfaces. These are being sourced from human proteins, from alternative immune molecules present in evolutionarily old vertebrates, and from highly evolved binding proteins in prokaryotic systems.
- Subjects :
- Microbiology (medical)
Public Health, Environmental and Occupational Health
Computational biology
Biology
Applied Microbiology and Biotechnology
Microbiology
DNA-binding protein
Immune surveillance
Alternative protein
Immune system
Immunity
Immunology
Protein microarray
biology.protein
Antibody
Human proteins
Subjects
Details
- ISSN :
- 13244272
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Microbiology Australia
- Accession number :
- edsair.doi...........89302a715945fa51fc3f4ba6f000ee72