Improved 2α-Hydroxylation Efficiency of Steroids by CYP154C2 Using Structure-Guided Rational Design

Authors :: Qilin Gao
Bingbing Ma
Qianwen Wang
Hao Zhang
Shinya Fushinobu
Jian Yang
Susu Lin
Keke Sun
Bing-Nan Han
Lian-Hua Xu
Source :: Applied and Environmental Microbiology. 89
Publication Year :: 2023
Publisher :: American Society for Microbiology, 2023.
Abstract: Hydroxylated derivatives of steroids play essential roles in medicine. Cytochrome P450 enzymes selectively hydroxylate methyne groups on steroids, which can dramatically change their polarity, biological activity and toxicity.

Subjects :: Ecology
Applied Microbiology and Biotechnology
Food Science
Biotechnology

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