ChemInform Abstract: Preparation of New 5-Aroylamino Substituted 3-Nicotinoyl/Isonicotinoyl-1,3,4-thiadiazol-2(3H)-ones with Anti-inflammatory Activity

A series of 1,3,4-thiadiazol-2(3H)-ones (2a–j) with a nicotinoyl/isonicotinoyl group in position 3 and an aroylamino substituent in position 5 of the ring was prepared and evaluated for antipyretic and anti-inflammatory activities. All the title compounds and in particular 2e, 2i and 2j exhibited anti-inflammatory activity and were devoid of antipyretic properties.