804 OVEREXPRESSION OF THE CANCER/TESTIS ANTIGEN JARID1B, CONTRIBUTES TO THE SURVIVAL OF PROSTATE CANCER CELLS UNDER ANDROGEN DEPLETED CONDITIONS

formin. Moreover, we also found that metformin inhibited expression of TWIST-1, a transcriptional activator of N-cadherin. Similar findings were observed by confocal microscopy. PC3 prostate cancer cells with stable over-expression of TWIST-1 became resistant to metforminmediated inhibition. CONCLUSIONS: We demonstrate that Metformin’s anti-cancer therapeutic effect may be mediated through repression of the TWIST/ N-cadherin signaling pathway.