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Acid stress upregulated outer membrane proteins in clinical isolates ofNeisseria gonorrhoeae, but not most commensalNeisseria

Authors :
R K Pettit
T M Whelan
K S Woo
Source :
Canadian Journal of Microbiology. 47:871-876
Publication Year :
2001
Publisher :
Canadian Science Publishing, 2001.

Abstract

Human immune serum recognition of outer membrane components from commensal and pathogenic Neisseria cultured under neutral and acidic conditions was investigated. Acid stress caused no detectable alterations in lipooligosaccharide migration and (or) staining, in outer membrane protein profiles, or in immune serum recognition of outer membrane components from Neisseria mucosa or Neisseria sicca. There was also no difference in the lipoologosaccharide electrophoretic pattern of acid- and neutral-grown Neisseria lactamica, but there were differences in outer membrane protein expression. The outer membrane protein alterations induced by acid stress in N. lactamica were not the same as those seen in isolates from patients with uncomplicated gonococcal infection, pelvic inflammatory disease, and disseminated gonococcal infection. Many differences were detected in the immune serum recognition of outer membrane components from acid- and neutral-cultured N. lactamica and from the clinical isolates of Neisseria gonorrhoeae, and these should be considered in vaccine design.Key words: Neisseria gonorrhoeae, commensal Neisseria, acid stress, outer membrane proteins.

Details

ISSN :
14803275 and 00084166
Volume :
47
Database :
OpenAIRE
Journal :
Canadian Journal of Microbiology
Accession number :
edsair.doi...........87a398b8a1aeac8502fb654deeb3705d
Full Text :
https://doi.org/10.1139/w01-087