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Therapeutic Potentials of BDNF/TrkB in Breast Cancer; Current Status and Perspectives
- Source :
- Journal of Cellular Biochemistry. 118:2502-2515
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- Brain-derived neurotrophic factor (BDNF) is a potent neurotrophic factor that has been shown to stimulate breast cancer cell growth and metastasis via tyrosine kinase receptors TrkA, TrkB, and the p75NTR death receptor. The aberrant activation of BDNF/TrkB pathways can modulate several signaling pathways, including Akt/PI3K, Jak/STAT, NF-kB, UPAR/UPA, Wnt/β-catenin, and VEGF pathways as well as the ER receptor. Several microRNAs have been identified that are involved in the modulation of BDNF/TrkB pathways. These include miR-206, miR-204, MiR-200a/c, MiR-210, MiR-134, and MiR-191; and these may be of value as prognostic and predictive biomarkers for detecting patients at high risk of developing breast cancer. It has been also been demonstrated that a high expression of genes involved in the BDNF pathway in breast cancer is associated with poor clinical outcome and reduced survival of patients. Several approaches have been developed for targeting this pathway, for example TKr inhibitors (AZD6918, CEP-701) and RNA interference. The aim of the current review was to provide an overview of the role of BDNF/TrkB pathways in the pathogenesis of breast cancer and its value as a potential therapeutic target. J. Cell. Biochem. 118: 2502-2515, 2017. © 2017 Wiley Periodicals, Inc.
- Subjects :
- 0301 basic medicine
Brain-derived neurotrophic factor
biology
business.industry
Wnt signaling pathway
Cell Biology
Tropomyosin receptor kinase B
Tropomyosin receptor kinase A
Biochemistry
Receptor tyrosine kinase
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
nervous system
Neurotrophic factors
030220 oncology & carcinogenesis
Immunology
biology.protein
Cancer research
Low-affinity nerve growth factor receptor
Medicine
business
Molecular Biology
PI3K/AKT/mTOR pathway
Subjects
Details
- ISSN :
- 07302312
- Volume :
- 118
- Database :
- OpenAIRE
- Journal :
- Journal of Cellular Biochemistry
- Accession number :
- edsair.doi...........87a286ae4f954503f26237e1fd3904ad