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Impact of Original and Artificially Improved Artificial Intelligence–based Computer-aided Diagnosis on Breast US Interpretation
- Source :
- Journal of Breast Imaging. 3:301-311
- Publication Year :
- 2021
- Publisher :
- Oxford University Press (OUP), 2021.
-
Abstract
- Objective For breast US interpretation, to assess impact of computer-aided diagnosis (CADx) in original mode or with improved sensitivity or specificity. Methods In this IRB approved protocol, orthogonal-paired US images of 319 lesions identified on screening, including 88 (27.6%) cancers (median 7 mm, range 1–34 mm), were reviewed by 9 breast imaging radiologists. Each observer provided BI-RADS assessments (2, 3, 4A, 4B, 4C, 5) before and after CADx in a mode-balanced design: mode 1, original CADx (outputs benign, probably benign, suspicious, or malignant); mode 2, artificially-high-sensitivity CADx (benign or malignant); and mode 3, artificially-high-specificity CADx (benign or malignant). Area under the receiver operating characteristic curve (AUC) was estimated under each modality and for standalone CADx outputs. Multi-reader analysis accounted for inter-reader variability and correlation between same-lesion assessments. Results AUC of standalone CADx was 0.77 (95% CI: 0.72–0.83). For mode 1, average reader AUC was 0.82 (range 0.76–0.84) without CADx and not significantly changed with CADx. In high-sensitivity mode, all observers’ AUCs increased: average AUC 0.83 (range 0.78–0.86) before CADx increased to 0.88 (range 0.84–0.90), P < 0.001. In high-specificity mode, all observers’ AUCs increased: average AUC 0.82 (range 0.76–0.84) before CADx increased to 0.89 (range 0.87–0.92), P < 0.0001. Radiologists responded more frequently to malignant CADx cues in high-specificity mode (42.7% vs 23.2% mode 1, and 27.0% mode 2, P = 0.008). Conclusion Original CADx did not substantially impact radiologists’ interpretations. Radiologists showed improved performance and were more responsive when CADx produced fewer false-positive malignant cues.
- Subjects :
- 03 medical and health sciences
0302 clinical medicine
Radiological and Ultrasound Technology
Breast imaging
Computer-aided diagnosis
business.industry
Computer science
030220 oncology & carcinogenesis
Interpretation (philosophy)
Radiology, Nuclear Medicine and imaging
Artificial intelligence
business
030218 nuclear medicine & medical imaging
Subjects
Details
- ISSN :
- 26316129 and 26316110
- Volume :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of Breast Imaging
- Accession number :
- edsair.doi...........8762c5d96838c6fd4ff7d6097bf10b67