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Anti-Growth Factor Receptor Antibodies as Therapy for Cancer
- Source :
- Cytotoxic Anticancer Drugs: Models and Concepts for Drug Discovery and Development ISBN: 9781461365488
- Publication Year :
- 1992
- Publisher :
- Springer US, 1992.
-
Abstract
- The idea of attacking cancer cells at the cell surface was revived in the past decade by the availability of monospecific heteroantisera. Phase I trials using monoclonal antibodies to most tumor cell antigens have shown little anti-tumor activity (Reviewed in 1,2). The reasons for these failures are complex, but include heterogeneity of tumor antigen expression; antibodyinduced antigen modulation from the cell surface; formation of human anti-mouse antibodies; and the uncertain efficacy of the host cell anti-tumor response (1,2). Immunoconjugates employing monoclonal antibodies as carriers for toxins, drugs, or radioisotopes and chimeric human-mouse monoclonal antibodies remain under investigation (1,2).
Details
- ISBN :
- 978-1-4613-6548-8
- ISBNs :
- 9781461365488
- Database :
- OpenAIRE
- Journal :
- Cytotoxic Anticancer Drugs: Models and Concepts for Drug Discovery and Development ISBN: 9781461365488
- Accession number :
- edsair.doi...........8743d81766999208adc54bd30871a14d