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Modeling mechanical properties of polyhydroxyalkanoate during degradation in animal tissue
- Source :
- Polymers for Advanced Technologies. 28:1879-1883
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- Polyhydroxyalkanoates (PHAs) are a family of biodegradable and biocompatible polymers produced by several species microorganisms that possess favorable mechanical properties (e.g. strength and elongation properties). Different types of PHA polymers have been used in medical applications. However, in order to better understand the use of this polymer in the different applications, a thorough understanding of the kinetics of in vivo degradation is one of the major requirements. In this study, poly(3-hydroxybutyrate) (PHB) was subcutaneously implanted in mice and incubated for 2, 4, 8, or 16 weeks. After removal from the animal, the strength, elongation, mass loss, and enthalpy of the PHB were tested for each time point. From these data, a mathematical model was generated by Rayleigh's method of dimensional analysis, where polymer strength over tissue contact time could be predicted. To prove the model, previous data obtained by our group were used: poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) [P(HB-co-HHx)] incubation in the presence of human embryonic kidney cells (HEK). It was found that the developed model was aligned with experimental results, could predict the strength of the polymer when in contact with cells, and the predicted strength follows the trend of the experimental data. Also, the dimensionless constant (K) value associated with the model is different for both experiments, where this constant, produced via experimental data, is used for construction of a homogeneous equation. Copyright © 2017 John Wiley & Sons, Ltd.
- Subjects :
- 0301 basic medicine
chemistry.chemical_classification
Materials science
Polymers and Plastics
Enthalpy
Kinetics
HEK 293 cells
02 engineering and technology
Polymer
021001 nanoscience & nanotechnology
Polyhydroxyalkanoates
03 medical and health sciences
030104 developmental biology
Chemical engineering
chemistry
Polymer chemistry
Degradation (geology)
Elongation
0210 nano-technology
Dimensionless quantity
Subjects
Details
- ISSN :
- 10427147
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Polymers for Advanced Technologies
- Accession number :
- edsair.doi...........873ddd304df794a57a6c51bb277edf94