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Ibuprofen suspension in the treatment of juvenile rheumatoid arthritis
- Source :
- The Journal of Pediatrics. 117:645-652
- Publication Year :
- 1990
- Publisher :
- Elsevier BV, 1990.
-
Abstract
- Ninety-two children with juvenile rheumatoid arthritis were randomly assigned to treatment in a multicenter, double-blind, 12-week trial designed to compare the efficacy and safety of a liquid formulation of ibuprofen at a dosage of 30 to 40 mg/kg/day versus those of aspirin at a dosage of 60 to 80 mg/kg/day. No significant intergroup differences in response rates or in the amount of improvement in articular indexes of disease activity were observed. More children treated with aspirin discontinued treatment early because of adverse reactions. After this trial, 84 additional patients with juvenile rheumatoid arthritis entered a 24-week, multidose (30, 40, and 50 mg/kg/day), open trial of ibuprofen suspension. Favorable response rates for the three groups were similar, and continued improvement was observed throughout the 24-week period. A dose-response relationship was observed with respect to adverse reactions of the upper gastrointestinal tract. We conclude that ibuprofen suspension is an effective nonsteroidal antlinflammatory drug and that its tolerability in children is acceptable.
- Subjects :
- Drug
medicine.medical_specialty
Aspirin
business.industry
media_common.quotation_subject
Arthritis
Ibuprofen
medicine.disease
Gastroenterology
Surgery
law.invention
Clinical trial
Randomized controlled trial
Tolerability
law
Internal medicine
Pediatrics, Perinatology and Child Health
medicine
business
Juvenile rheumatoid arthritis
medicine.drug
media_common
Subjects
Details
- ISSN :
- 00223476
- Volume :
- 117
- Database :
- OpenAIRE
- Journal :
- The Journal of Pediatrics
- Accession number :
- edsair.doi...........87234c3bd5cab5a0a5591fe2dff1665c