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15-Deoxy-Δ12,14-prostaglandin J2 up-regulates the expression of 15-hydroxyprostaglandin dehydrogenase through DNA methyltransferase 1 inactivation
- Source :
- Free Radical Research. 53:335-347
- Publication Year :
- 2019
- Publisher :
- Informa UK Limited, 2019.
-
Abstract
- 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is the key enzyme that catalyses the conversion of prostaglandin E2 to a keto metabolite. The expression of 15-PGDH is ubiquitously repressed in vari...
- Subjects :
- 0301 basic medicine
chemistry.chemical_classification
030102 biochemistry & molecular biology
Chemistry
Metabolite
Dehydrogenase
General Medicine
Methylation
Biochemistry
DNA methyltransferase
03 medical and health sciences
chemistry.chemical_compound
030104 developmental biology
Enzyme
15 hydroxyprostaglandin dehydrogenase
medicine
DNMT1
lipids (amino acids, peptides, and proteins)
Prostaglandin E2
medicine.drug
Subjects
Details
- ISSN :
- 10292470 and 10715762
- Volume :
- 53
- Database :
- OpenAIRE
- Journal :
- Free Radical Research
- Accession number :
- edsair.doi...........8721870eb50f8f0cd5180a5a84b8bfd8
- Full Text :
- https://doi.org/10.1080/10715762.2019.1576867