The delivery of dinitrosyl iron complexes into animal lungs

The effective accumulation of binuclear dinitrosyl iron complexes with glutathione was shown after subcutaneous perilymphatic injection of an aqueous solution of dinitrosyl iron complexes into animal lung tissue at a single dose of 2 µmol per kg twice a day with an interval of 2 h. At 2 hours after the repeated administration, the concentration of these complexes was 16 µmol per kg of the tissue, which decreased during the last 2 hours to 7 μmol per kg of the tissue. Upon a single injection of binuclear dinitrosyl iron complexes with glutathione, their concentration 2 and 4 hours later was two times lower than that in the previous experiments. Presumably, at the obtained concentrations of dinitrosyl iron complexes, a bactericidal effect in the lungs could be observed against Mycobacterium tuberculosis and rapidly proliferating lung tumors.