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The softness of tumour-cell-derived microparticles regulates their drug-delivery efficiency
- Source :
- Nature Biomedical Engineering. 3:729-740
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Extracellular microparticles (MPs) can function as drug-delivery vehicles for anticancer drugs. Here, we show that the softness of MPs derived from tumour-repopulating cells (TRCs) isolated from three-dimensional fibrin gels enhances the MPs' drug-delivery efficiency. We found that, compared with MPs derived from tumour cells cultured in conventional tissue-culture plastic, TRC-derived MPs intravenously injected in tumour-xenograft-bearing mice showed enhanced accumulation in tumour tissues, enhanced blood-vessel crossing and penetration into tumour parenchyma, and preferential uptake by highly tumorigenic TRCs. We also show that the cytoskeleton-related protein cytospin-A plays a critical role in the regulation of TRC-derived MP softness. The modulation of the mechanical properties of TRC-derived MPs could aid the efficiency of delivery of anticancer drugs.
- Subjects :
- 0301 basic medicine
congenital, hereditary, and neonatal diseases and abnormalities
Biomedical Engineering
Medicine (miscellaneous)
Bioengineering
Fibrin
Cell-Derived Microparticles
03 medical and health sciences
0302 clinical medicine
stomatognathic system
Parenchyma
Extracellular
skin and connective tissue diseases
Cytoskeleton
biology
Chemistry
nutritional and metabolic diseases
Computer Science Applications
Cell biology
030104 developmental biology
Apoptosis
Cell culture
Drug delivery
biology.protein
030217 neurology & neurosurgery
Biotechnology
Subjects
Details
- ISSN :
- 2157846X
- Volume :
- 3
- Database :
- OpenAIRE
- Journal :
- Nature Biomedical Engineering
- Accession number :
- edsair.doi...........86f1518578059634c3d0631df2e90509