Factors Associated with Early Mortality in Patients Undergoing Allogeneic Stem Cell Transplantation

Background Allogeneic stem cell transplantation (AlloSCT) is a curative procedure for many hematologic neoplasms. Majority of the AlloSCT require an initial hospitalization and a mortality rate of up to 8% during the SCT hospitalization has been previously reported (Ballen et al, 2014 BBMT). Role of patient-, disease- and transplant-related factors in predicting early mortality during transplant hospitalization has not been previously investigated. We sought to analyze the predictors of inpatient mortality in patients undergoing AlloSCT from a large administrative database, National Inpatient Sample (NIS). Methods International Classification of Diseases, Ninth Revision (ICD-9) procedure codes were used to identify patients undergoing AlloSCT in the 2002-2015 NIS database whereas ICD-9 diagnosis codes were used to assess complications of Allo-SCT. Early transplant-related mortality was defined as death during the hospitalization for SCT. Chi-square was used for categorical data comparisons (p Results During the study period of 2002-2015, we identified 68,296 hospitalizations (median age 50 years and 58% male) undergoing inpatient AlloSCT (baseline characteristics in table 1 & figure 1); death occurred in 5,198 (7.6%). Age Conclusion Our analysis identified novel prognostic and predictive factors associated with higher inpatient mortality during SCT hospitalization. Identifying at risk patients can provide an opportunity for early intervention and improving post-transplant outcomes.