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Microsponges: A Neoteric approach for the effective management of Osteoarthritis

Authors :
Anjali Sharma
Priyanka Kriplani
Shiwani Sen
Kumar Guarve
Source :
Current Rheumatology Reviews. 19
Publication Year :
2023
Publisher :
Bentham Science Publishers Ltd., 2023.

Abstract

Background: A microsponge delivery system (MDS) is a cutting-edge and distinctive method of structured medication delivery. Regulated drug distribution is now possible with the use of microsponge technology. Techniques for drug release are created specifically to distribute medications to the body's various locations. As a result, pharmacological therapy becomes more effective, and patient compliance significantly affects the health care system. Main Body: MDS consists of porous microspheres with a substantially porous structure and a very small spherical shape, ranging in size from 5 to 300 microns. MDS is typically used to administer medications through topical channels, but new research has demonstrated the promise of this technique for parenteral, oral, and ocular drug delivery. Topical formulations are an attempt to manage diseases like osteoarthritis, rheumatoid arthritis, psoriasis, etc. While reducing the drug's side effects, MDS can readily change the pharmaceutical release shape and enhance formulation stability. Reaching the highest peak plasma concentration in the blood is the main goal of microsponge medication delivery. The ability of MDS to self-sterilize is by far the most notable quality. Conclusion: In countless studies, MDS is employed as an anti-allergic, anti-mutagenic, and nonirritant. This review covers the overview of microsponges along with their release mechanism. The article focuses on the marketed formulation of microsponges and patent data of the same. This review will be helpful for researchers working in MDS technology.

Subjects

Subjects :
Rheumatology

Details

ISSN :
15733971
Volume :
19
Database :
OpenAIRE
Journal :
Current Rheumatology Reviews
Accession number :
edsair.doi...........86c3cc4d3e2275460192606c09828ca4
Full Text :
https://doi.org/10.2174/1573397119666230417093138