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Intercellular adhesion molecule expression in ductal carcinoma of the breast
- Source :
- Diagnostic Cytopathology. 23:73-76
- Publication Year :
- 2000
- Publisher :
- Wiley, 2000.
-
Abstract
- Recent studies suggest that altered expression of intercellular adhesion molecules (ICAM) in ductal carcinoma of the breast is associated with a higher incidence of metastases and decreased patient survival. In addition, the presence of significant cellular dyscohesion in cytologic smear preparations has been found to correlate with the presence of regional and distant metastases in a subset of patients. In this study, we correlate the smear pattern in preparations taken directly from surgically excised breast tumors with their immunohistochemical staining pattern, using antibodies directed against a panel of ICAM. We found excellent correlation, as all three tumors with an extremely high degree of tumor cell cohesion showed strong staining with all ICAM antibodies in the vast majority (>/=90%) of tumor cells in corresponding tissue sections. In contrast, five tumors displaying a largely dyscohesive smear pattern demonstrated decreased staining (
- Subjects :
- Pathology
medicine.medical_specialty
Histology
business.industry
Cell adhesion molecule
Intercellular Adhesion Molecule-1
General Medicine
Ductal carcinoma
Intercellular adhesion molecule
Pathology and Forensic Medicine
Staining
Cytopathology
Medicine
Immunohistochemistry
business
Breast carcinoma
Subjects
Details
- ISSN :
- 10970339 and 87551039
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Diagnostic Cytopathology
- Accession number :
- edsair.doi...........86a64387403c3406c1fe08926a9d4a67