Prognostic Significance of the Tumor Volume and Tumor Percentage for Localized Prostate Cancer

Purpose: Tumor volume has been thought to be an important predictive factor for significant prostate cancer. We assessed the impact of the tumor volume (TV) and the tumor percentage (TP) of radical prostatectomy specimens on the pathological variables and the oncological outcome. Materials and Methods: The tumor percentage and tumor volume were calculated for 525 cases by a single pathologist who determined the volume based on the surface area of the slides involved by tumor of the prostate. Univariate and multivariate logistic regression analyses were used to characterize the association of TP categories (＜5%, 5-10%, 11-20% and ＞20%) and TV (＜1.8cc, 1.8-3.7cc, 3.8-7.5cc, ＞7.5cc) with the clinicopathological variables. Biochemical recurrence (BCR) was estimated using Kaplan-Meier analysis and Cox’s hazard regression model. Results: The mean prostate cancer volume was 6.5±8.5cc (median: 3.8, range: 0.04-73.8) and the mean percent tumor composition was 0.17±0.19