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A fluorescent probe operating under weak acidic conditions for the visualization of HOCl in solid tumors in vivo
- Source :
- Science China Chemistry. 63:1153-1158
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Levels of reactive oxygen species (ROS) in cancer cells or in the tumor microenvironment differ noticeably from those in normal cells and cellular microenvironments because ROS play important roles in all aspects of tumor physiology. However, due to the lack of adequate tools, it is difficult to study the relationship between ROS, especially certain types of ROS (e.g., HOCl), and cancer. We report herein an HOCl-specific fluorescent probe, FDOCl-20, containing a thiocarbamide group as a receptor, for the visualization of HOCl in solid tumors in vivo. This probe displays high selectivity and sensitivity to HOCl, and is appropriate for use in acidic conditions, including the tumor microenvironment. Using FDOCl-20 as a tool, we can visualize HOCl in solid tumors in vivo. Importantly, the fluorescent intensity of FDOCl-20 is proportional to tumor volume. Thus, FDOCl-20 is a useful tool to investigate the relationship between HOCl and the physiological processes of tumors.
- Subjects :
- chemistry.chemical_classification
Reactive oxygen species
Tumor microenvironment
Hypochlorous acid
010405 organic chemistry
Cancer
General Chemistry
010402 general chemistry
medicine.disease
01 natural sciences
Fluorescence
0104 chemical sciences
chemistry.chemical_compound
chemistry
In vivo
Cancer cell
medicine
Biophysics
Receptor
Subjects
Details
- ISSN :
- 18691870 and 16747291
- Volume :
- 63
- Database :
- OpenAIRE
- Journal :
- Science China Chemistry
- Accession number :
- edsair.doi...........86950ad987bd8b83303ba354122dac72