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Conformationally restricted analogues of methionine: Synthesis of chiral 3-Amino-5-methylthio-2-piperidones
- Source :
- Tetrahedron. 52:7727-7736
- Publication Year :
- 1996
- Publisher :
- Elsevier BV, 1996.
-
Abstract
- (αR, 3RS, 5S)-3-Amino-N-(2-hydroxy-1-phenylethyl)-5-methylthio-2-piperidones1 have been synthesized from enamide 2 by subsequent free radical addition of methanothiol on position 5 and amination of 3-position.
Details
- ISSN :
- 00404020
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Tetrahedron
- Accession number :
- edsair.doi...........864dc771bcdec8c834b9964ddc4044ee
- Full Text :
- https://doi.org/10.1016/s0040-4020(96)00340-7