Association of Akt inhibition with change in immunophenotype of tumor microenvironment (TME) in breast cancer (BC)

Authors :: Douglas K. Marks
Yan Lu
Kevin Kalinsky
Thomas D. Hart
Hanina Hibshoosh
Eileen P. Connolly
Margueritta El Asmar
Yvonne M. Saenger
Camden L Esancy
Shuobo Boboila
Robyn D. Gartrell
Source :: Journal of Clinical Oncology. 36:12057-12057
Publication Year :: 2018
Publisher :: American Society of Clinical Oncology (ASCO), 2018.
Abstract: 12057Background: The PI3K/Akt/mTOR pathway is a known regulator of oncogenic growth in BC. In addition, this pathway also modulates host immune function and may indirectly affect tumorigenesis. Cli...

Subjects :: Cancer Research
Tumor microenvironment
business.industry
Regulator
medicine.disease
medicine.disease_cause
body regions
Breast cancer
Immune system
Immunophenotyping
Oncology
medicine
Cancer research
business
Carcinogenesis
Protein kinase B
PI3K/AKT/mTOR pathway

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