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Involvement of A2B adenosine receptors as anti-inflammatory in gestational diabesity
- Source :
- Molecular Aspects of Medicine. 66:31-39
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Pregnant women that are obese may develop gestational diabetes mellitus (GDM) configuring a new metabolic condition referred to as gestational diabesity. The metabolic alterations seen in gestational diabesity include a combination of an exacerbated pro-inflammatory state and fetoplacental endothelial dysfunction. Also, gestational diabesity associates with supra-physiological extracellular concentration of adenosine in the foetoplacental blood. Since adenosine plays a central role in the inflammatory response in GDM and obesity, it is likely that this nucleoside will play a similar role in gestational diabesity. However, the effect of adenosine in the foetoplacental vasculature in this condition is not yet addressed. Adenosine exerts its biological actions via four adenosine receptors. Activation of A2B adenosine receptors (A2BAR) subtype associates with an anti-inflammatory response in several tissue and diseases. In tissues from pregnant women with GDM, there is an overexpression of A2BAR, and higher mRNA expression of ADORA2B (for A2BAR) was shown to correlate with hyperglycaemia and oxidative stress. A2BAR shows low affinity for adenosine (micromolar) and its activation results in triggering intracellular signalling cascades lowering the inflammatory response. This phenomenon requires a high level of extracellular adenosine in diseases of pregnancy such as GDM or gestational diabesity. In this review, we focused on the role of A2BAR involvement in the biological actions of adenosine on inflammation in the foetoplacental vasculature in gestational diabesity. Some factors including oxidative stress and hypoxia in this phenomenon are discussed.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Clinical Biochemistry
Inflammation
medicine.disease_cause
Biochemistry
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Endothelial dysfunction
Molecular Biology
business.industry
General Medicine
Hypoxia (medical)
medicine.disease
Adenosine receptor
Adenosine
Gestational diabetes
030104 developmental biology
Endocrinology
030220 oncology & carcinogenesis
Molecular Medicine
medicine.symptom
business
Adenosine A2B receptor
Oxidative stress
medicine.drug
Subjects
Details
- ISSN :
- 00982997
- Volume :
- 66
- Database :
- OpenAIRE
- Journal :
- Molecular Aspects of Medicine
- Accession number :
- edsair.doi...........85bbd1ea7d240c2e7038e2b521a836dd