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ChemInform Abstract: Synthesis, SAR and Intramolecular Hydrogen Bonding Pattern of 1,3,5-Trisubstituted 4,5-Dihydropyrazoles as Potent Cannabinoid CB1 Receptor Antagonists
- Source :
- ChemInform. 41
- Publication Year :
- 2010
- Publisher :
- Wiley, 2010.
-
Abstract
- The synthesis, structure–activity relationship (SAR) studies and intramolecular hydrogen bonding pattern of 1,3,5-trisubstituted 4,5-dihydropyrazoles are described. The target compounds 6–18 represent a novel class of potent and selective CB1 receptor antagonists. Based on X-ray diffraction data, the orally active 17 is shown to elicit a different intramolecular H-bonding mode as compared to ibipinabant (3) and SLV330 (4).
Details
- ISSN :
- 15222667 and 09317597
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- ChemInform
- Accession number :
- edsair.doi...........8449671cf6ec8952e4dd6753e60a5351