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Single-Laboratory Validation of a Method for the Detection and/or Quantification of Select Alkaloids in Goldenseal Supplements and Raw Materials by Reversed-Phase High-Performance Liquid Chromatography
- Source :
- Pharmaceutical Biology. 46:135-144
- Publication Year :
- 2008
- Publisher :
- Informa UK Limited, 2008.
-
Abstract
- Quality of botanical products and raw materials is important to manufacturers, regulators, researchers, and consumers. Many modern botanical quality-assurance schemes set specifications for select phytochemicals and measure against those specifications as one determinant of quality. While numerous publications describe procedures for determining compounds of interest in plant species, few methods have been systematically evaluated for accuracy, precision, or reliability, and often the analysis of finished products is not within the scope of the method. Hydrastis canadensis. L., commonly referred to as Goldenseal, is an economically important North American medicinal plant that has been subject to adulteration in commerce. The phytochemicals of interest in the plant are the alkaloids hydrastine, berberine, and canadine. Of interest is also palmatine, an alkaloid found in potential adulterant species but not in goldenseal. In this study, goldenseal materials in raw, capsule, and tablet form, includi...
- Subjects :
- Pharmacology
Adulterant
biology
Traditional medicine
business.industry
Pharmaceutical Science
Palmatine
General Medicine
Raw material
biology.organism_classification
High-performance liquid chromatography
Hydrastine
Biotechnology
Canadine
chemistry.chemical_compound
Complementary and alternative medicine
chemistry
Drug Discovery
Plant species
medicine
Molecular Medicine
business
Goldenseal
Mathematics
medicine.drug
Subjects
Details
- ISSN :
- 17445116 and 13880209
- Volume :
- 46
- Database :
- OpenAIRE
- Journal :
- Pharmaceutical Biology
- Accession number :
- edsair.doi...........844004780961fa52d977d00215c012e1