ChemInform Abstract: Utilization of Tetrabutylammonium Triphenyldifluorosilicate (TBAT) in the Synthesis of 6-Fluoropurine Nucleosides

Tetrabutylammonium triphenydifluorosilicate (TBAT) has been found to be a useful reagent for the conversion of 6-chloropurine nucleosides to 6-fluoropurine derivatives. The 6-chloropurine nucleosides were reacted with trimethylamine to form quaternary trimethylammonium salts which were treated in situ with TBAT in DMF to effect conversion to the 6-fluoro derivatives in yields of 59–72%.