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Radioiodinated ?1-adrenergic receptor ligands
- Source :
- Journal of Labelled Compounds and Radiopharmaceuticals. 44:61-72
- Publication Year :
- 2001
- Publisher :
- Wiley, 2001.
-
Abstract
- The synthesis and preliminary characterization of three radioiodinated α1-adrenergic receptor ligands [125I]5a–c are described. These tracers are analogs of L-760,478, 1b, itself an analog of prazosin, 1a. The highest affinity tracer, [125I]5a, has six fold higher affinity for the α1 receptor subtypes than prazosin. These ligands could be useful for autoradiographic studies of the α1 receptor subtypes. Copyright © 2001 John Wiley & Sons, Ltd.
- Subjects :
- Bicyclic molecule
Ligand
Stereochemistry
Chemistry
Organic Chemistry
Biological activity
Biochemistry
α1 adrenergic receptor
Chemical synthesis
Analytical Chemistry
Drug Discovery
Prazosin
medicine
Radiology, Nuclear Medicine and imaging
Receptor
Spectroscopy
Alpha-1 adrenergic receptor
medicine.drug
Subjects
Details
- ISSN :
- 10991344 and 03624803
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- Journal of Labelled Compounds and Radiopharmaceuticals
- Accession number :
- edsair.doi...........83b195c9c2928d536ebf2794910f224f