Radioiodinated ?1-adrenergic receptor ligands

The synthesis and preliminary characterization of three radioiodinated α1-adrenergic receptor ligands [125I]5a–c are described. These tracers are analogs of L-760,478, 1b, itself an analog of prazosin, 1a. The highest affinity tracer, [125I]5a, has six fold higher affinity for the α1 receptor subtypes than prazosin. These ligands could be useful for autoradiographic studies of the α1 receptor subtypes. Copyright © 2001 John Wiley & Sons, Ltd.