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Transition-metal-free decarbonylative alkylation towards N-aryl α-hydroxy amides via triple C–C bond cleavages and their selective deuteration
- Source :
- Organic Chemistry Frontiers. 8:4814-4819
- Publication Year :
- 2021
- Publisher :
- Royal Society of Chemistry (RSC), 2021.
-
Abstract
- We disclose a transition-metal-free decarbonylative alkylation reaction for the synthesis of N-aryl α-hydroxy amides via precise cleavages and reorganizations of three C–C σ bonds. For the first time, a medium-sized cycloalkyl was used as a leaving group to initiate the decarbonylative alkylation process. We also demonstrate the concept of “one-pot” inert C–C bond activation/deuteration. This strategy allows the formation of α,β-deuterated hydroxyamides by using DMSO-d6 as a solvent.
Details
- ISSN :
- 20524129
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Organic Chemistry Frontiers
- Accession number :
- edsair.doi...........839a92683d93b38843252dc128d20e3c