Effect of fenfluramine, a 5HT releaser/uptake inhibitor on neurological recovery following spinal cord injury in rats

The present study was designed to assess the effect of fenfluramine, a 5-HT releaser/uptake inhibitor, on neurological recovery following spinal cord injury (SCI) in rats. Sprague Dawley male rats were subjected to compression injury at T11 level for five minutes with a load of 35g. Posttraumatic neurological recovery was assessed for 10 days using Tarlov score, Rivlin-Tator angle board and sensory and vocal score. The results of this study showed that fenfluramine in a dose of 5 mg/kg significantly delayed the recovery from spinal cord injury.