Advances in the enzymatic biofuel cell powered sensing systems for tumor diagnosis and regulation

Tumors are the leading killers of human health, however, diagnosis on tumors are neither timely nor accurate due to the high detection cost and high technical requirements. For cancer diagnosis and treatment, self-powered biosensors based on enzymatic biofuel cells have the advantages of simple structure, easy miniaturization, instantaneous response to analytes, and high economic applicability. It is of great significance for the development of portable and personalized biosensors. Over the past twenty years, a number of prominent self-powered biosensors have been created to diagnose tumor via analyzing the corresponding biomarkers with low cost. What’s more, some intelligent self-powered biosensors with integrated diagnostic and therapeutic functions have also been reported. In this review, the focus of this work is on the development of self-powered biosensors in tumor diagnosis and intelligent regulation from the aspects of design and working principles. Furthermore, the challenge for the future work is also analyzed.