Cleavage of hindered α-methylbenzylamides, intermediates in the resolution of carboxylic acids

Authors :: Jocelyn G. Millar
Robert M. Silverstein
Francis X. Webster
Source :: Tetrahedron Letters. 27:4941-4944
Publication Year :: 1986
Publisher :: Elsevier BV, 1986.
Abstract: α-Methylbenzylamides, useful intermediates in the resolution of carboxylic acids, are cleaved with a two step procedure; enolizable amides are not racemized.

Subjects :: chemistry.chemical_classification
Bicyclic molecule
medicine.drug_class
Stereochemistry
Carboxylic acid
Organic Chemistry
Carboxamide
Cleavage (embryo)
Biochemistry
chemistry.chemical_compound
Acyl chloride
chemistry
Hydrogenolysis
Drug Discovery
medicine
Aliphatic compound
Bond cleavage

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