Oral adjuvant treatment choices and local recurrence risk in early stage breast cancer

10625 Background: Among women (W) with early-stage breast cancer (BC) treated with lumpectomy and radiation therapy (RT), those who also receive oral adjuvant therapy (OAT) have a lower risk of local recurrence (LR). The purpose of this study was to evaluate the associations of age (A), race/ethnicity (RE), education (E), socioeconomic status (SS), LR rate, and knowledge about potential side effects (SE) with W’s willingness to receive OAT. Methods: Between 6/05 and 9/05, we asked W with (+) and without (−) BC to participate in an IRB-approved survey. The survey questionnaire presented W with clinical vignettes including information about RT ± 5 years of OAT and the LR and SE associated with treatment options. It then asked W to choose between the treatment options and to rate them, using a time trade-off method, given LR and SE. Results: The distribution of the 161 respondents (55 (+)BC and 106 (−)BC) by A, RE, E, SS is shown in the table below. A and RE were associated with a W’s choice of combined modality treatment (CMT) consisting of RT and OAT, to decrease the risk of LR (p < 0.009 and p < 0.056). Stratified analysis showed an association between CMT and E (p < 0.006) in W (+)BC; A (p < 0.04) and SS (p < 0.04) were associated with CMT choice when SE were described. In W (−) BC, RE (p < 0.02) and SS (p < 0.04) were associated with CMT choice when SE were described. Compared to W who had used oral contraceptive agents (OCA), women who did not use OCA were 45% less likely to trade time to decrease their risk of LR by taking OAT when told about similar SE between OCA and OAT (OR = 0.55, 95% CI 0.28, 1.09), but this association was not statistically significant. Conclusions: W of various A, RE, E and SS who were given information about treatment choices with LR rates chose therapies that gave them the best chance of disease-free survival. For W (+) BC history, level of E significantly influenced the choice to proceed with CMT. A, RE and SS influenced CMT choice when SE were described. W who had used OCA in the past may have been less concerned than others about potential side effects of OAT. [Table: see text] No significant financial relationships to disclose.