MP80-18 LOW UTILIZATION OF ADJUVANT THERAPY FOR ADVERSE PATHOLOGIC FEATURES FOLLOWING RADICAL PROSTATECTOMY IN AFRICAN AMERICANS DOES NOT TRANSLATE TO AN INCREASED RISK OF BIOCHEMICAL RECURRENCE

INTRODUCTION AND OBJECTIVES: There is an ongoing debate on removing the label of cancer from Gleason 6 tumors. The aim of the study was to analyze long-term oncological outcomes in patients with pathologic Gleason 3+3 score after radical prostatectomy and to add further knowledge to the discussion. METHODS: We retrospectively analyzed the data of 2942 patients who underwent RP between January 1998 and 2010 and showed a Gleason score 3þ3 in final pathology. Biochemical recurrence (BCR)-free survival, metastasis-free survival (MFS) and cancer-specific survival (CSS) was reported. In multivariate regression analyses further prognosticators of oncological outcome in these patients were analyzed. RESULTS: Median follow-up was 80.7 months. 795 (27.1%) patients underwent lymph node dissection, whereas only one of these patients had positive lymph nodes. Mean preoperative PSA was 6.6 ng/ml, 9.1% of patients had a positive surgical margin and 94.4% had an organ-confined tumor. 198 patients (7.2%) recurred during the follow-up period, 15 (0.5%) patients developed metastasis and 7 (0.2%) patients died of their disease. Patients developing metastases had a significantly higher preoperative PSA (p1⁄40.03) and were more likely to harbor a non-organ-confined tumor (p