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Addressing the gaps in homeostatic mechanisms of copper and copper dithiocarbamate complexes in cancer therapy: a shift from classical platinum-drug mechanisms

Authors :
Lydia W. Njenga
Simon N. Mbugua
Ruth A. Odhiambo
Martin O. Onani
Source :
Dalton Transactions. 52:5823-5847
Publication Year :
2023
Publisher :
Royal Society of Chemistry (RSC), 2023.

Abstract

This review will focus on copper homeostasis in mammalian cells and on our current understanding of copper dysregulation in cancer and recent therapeutic breakthroughs using copper coordination complexes as anticancer drugs.

Subjects

Subjects :
Inorganic Chemistry

Details

ISSN :
14779234 and 14779226
Volume :
52
Database :
OpenAIRE
Journal :
Dalton Transactions
Accession number :
edsair.doi...........826726be32020684fbff383a931635bf