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Polymorphism Screening of Four Genes Encoding Advanced Glycation End-Product Putative Receptors
- Source :
- Diabetes. 50:1214-1218
- Publication Year :
- 2001
- Publisher :
- American Diabetes Association, 2001.
-
Abstract
- Advanced glycation end-products (AGEs) may play an important role in the pathogenesis and progression of cardiovascular and renal complications of diabetes. Four putative AGE receptors (RAGEs), AGE-R1, AGE-R2, and AGE-R3 have been described. In this study, we scanned the sequence of the genes encoding these AGE receptors in 48 patients with type 1 diabetes and investigated the identified polymorphisms (n = 19) in 199 type 1 diabetic patients with nephropathy and 193 type 1 diabetic patients without nephropathy. Overall, none of the polymorphisms was strongly associated with nephropathy. The minor allele of a polymorphism located in the promoter region of the RAGE gene (C-1152A) conferred a weak protective effect (P < 0.05) and was associated with a longer duration of nephropathy-free diabetes (P = 0.08).
- Subjects :
- Type 1 diabetes
medicine.medical_specialty
business.industry
Endocrinology, Diabetes and Metabolism
medicine.disease
Nephropathy
Minor allele frequency
chemistry.chemical_compound
Endocrinology
chemistry
Glycation
Internal medicine
Diabetes mellitus
Immunology
Internal Medicine
medicine
Advanced glycation end-product
business
Receptor
Kidney disease
Subjects
Details
- ISSN :
- 1939327X and 00121797
- Volume :
- 50
- Database :
- OpenAIRE
- Journal :
- Diabetes
- Accession number :
- edsair.doi...........82446a2ea6d6a6524fb5f95e6db70d79