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Replication of DNA Satellites and Their Role in Viral Pathogenesis
- Source :
- Geminiviruses ISBN: 9783030182472
- Publication Year :
- 2019
- Publisher :
- Springer International Publishing, 2019.
-
Abstract
- The white-fly borne begomoviruses (family Geminiviridae) have circular single-stranded (css) DNA genome, which is encapsidated as monopartite (DNA-A) or bipartite (DNA-A and DNA-B) in the twinned icosahedrons. During the course of their evolution and to escape host defense machinery, begomoviruses adopt small cssDNA satellites called alpha-, beta-, and deltasatellites. Alphasatellties are found to be associated with begomovirus–betasatellite complexes and encode their own replication-associated protein (Rep), thus capable of autonomous replication. These satellite-like molecules are not well known to serve any critical function for their helper begomovirus except for few reports about attenuation of helper-virus accumulation and/or occasionally suppression of the host defense. Most of the monopartite begomoviruses in the Old World (OW) are found to be associated with betasatellites; however, none of the New World (NW) begomoviruses are known to be associated with betasatellites. Begomoviruses replicate their genome through rolling circle replication (RCR), which requires the virus-encoded Rep to recognize and bind to the iterated sequences (iterons) in the origin of replication (ori) region. Betasatellites lack such iterated sequences; however, they can be transreplicated by a diverse range of begomoviruses, following a similar pattern for replication. Betasatellites play a significant role in viral pathogenesis by interacting with certain host factors, attenuation of disease symptoms, suppression of host defense, and sometimes inter- or intracellular shuttling of begomovirus genome. Likewise, the noncoding molecules deltasatellites depend upon their helper virus for their replication. However, their precise role in viral pathogenesis still needs to be explored.
Details
- ISBN :
- 978-3-030-18247-2
- ISBNs :
- 9783030182472
- Database :
- OpenAIRE
- Journal :
- Geminiviruses ISBN: 9783030182472
- Accession number :
- edsair.doi...........823330e02d118eb27af1e2e1961373ce