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Optic pathway gliomas in neurofibromatosis-1: Controversies and recommendations
Optic pathway gliomas in neurofibromatosis-1: Controversies and recommendations
- Source :
- Annals of Neurology. 61:189-198
- Publication Year :
- 2007
- Publisher :
- Wiley, 2007.
-
Abstract
- Optic pathway glioma (OPG), seen in 15% to 20% of individuals with neurofibromatosis type 1 (NF1), account for significant morbidity in young children with NF1. Overwhelmingly a tumor of children younger than 7 years, OPG may present in individuals with NF1 at any age. Although many OPG may remain indolent and never cause signs or symptoms, others lead to vision loss, proptosis, or precocious puberty. Because the natural history and treatment of NF1-associated OPG is different from that of sporadic OPG in individuals without NF1, a task force composed of basic scientists and clinical researchers was assembled in 1997 to propose a set of guidelines for the diagnosis and management of NF1-associated OPG. This new review highlights advances in our understanding of the pathophysiology and clinical behavior of these tumors made over the last 10 years. Controversies in both the diagnosis and management of these tumors are examined. Finally, specific evidence-based recommendations are proposed for clinicians caring for children with NF1.
- Subjects :
- musculoskeletal diseases
congenital, hereditary, and neonatal diseases and abnormalities
medicine.medical_specialty
Pediatrics
Optic glioma
business.industry
Evidence-based medicine
medicine.disease
eye diseases
nervous system diseases
Surgery
Natural history
Central nervous system disease
Neurology
Glioma
medicine
Precocious puberty
Neurology (clinical)
Neurofibromatosis
Optic nerve glioma
business
neoplasms
Subjects
Details
- ISSN :
- 15318249 and 03645134
- Volume :
- 61
- Database :
- OpenAIRE
- Journal :
- Annals of Neurology
- Accession number :
- edsair.doi...........821da71085291be58c963cbbdbad8dc0
- Full Text :
- https://doi.org/10.1002/ana.21107