Changes of natural killer cell number and cytolytic activity during first trimester of pregnancy in recurrent spontaneous abortion patients and fertile control

Results %NK cells among peripheral blood lymphocyte in RSA patients before pregnancy was significantly higher than that of nonpregnant normal control. NK cell cytolytic activity in non-pregnant RSA patients was significantly higher than that of non-pregnant fertile group. After success to get pregnancy, NK cell cytolytic activity in RSA patients were decreased but were not significantly different compared to that of NK cell cytolytic activity checked at non-pregnant status. NK cell cytolytic activity in pregnant RSA patients was significantly higher than that of pregnant normal control.