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Cumulative insulin resistance and hyperglycemia with arterial stiffness and carotid IMT progression in 1,779 adolescents: a 9-yr longitudinal cohort study
- Source :
- American Journal of Physiology-Endocrinology and Metabolism. 324:E268-E278
- Publication Year :
- 2023
- Publisher :
- American Physiological Society, 2023.
-
Abstract
- Fasting plasma glucose, insulin, and insulin resistance had a J- or U-shaped increase from 15 to 24 yr with the base of the curve at age 17 yr. Cumulative high insulin and high insulin resistance from 15 to 24 yr were negatively associated with arterial stiffness progression from ages 17 to 24 yr. Age 17 yr may be an optimal timing for intervention targeted at sustaining the protective effect of the decline of insulin and insulin resistance on arterial stiffness progression.
- Subjects :
- Physiology
Physiology (medical)
Endocrinology, Diabetes and Metabolism
Subjects
Details
- ISSN :
- 15221555 and 01931849
- Volume :
- 324
- Database :
- OpenAIRE
- Journal :
- American Journal of Physiology-Endocrinology and Metabolism
- Accession number :
- edsair.doi...........8156b4dd152a4d2f3f97586d2760a0bc