Synthesis of Ophiocerin A and B

We also reported a carbohydrate-based approach to the total synthesis of ophiocerin C (3). The commercially available methyl α-D-glucopyranoside (5) was converted to the key intermediate 6, which was then transformed to the target compound 3. The successful synthesis of ophiocerin C led us to investigate the total synthesis of other ophiocerins. We, herein, report the synthesis of ophiocerin A (1) and B (2).