Bioactivity of Fe 2 O 3 -CaO-SiO 2 glass ceramics modified through the addition of P 2 O 5 and TiO 2

The bioactivity of ferromagnetic glass ceramics is one key factor affecting the success of hyperthermia treatments. In order to investigate the effect of the addition of a nucleating agent on the bioactivity of the resulting glass ceramics, two different nucleating agents were used for the fabrication of Fe 2 O 3 -CaO-SiO 2 glass ceramics, and their short-term and long-term effects on the cytotoxicity of human fetal normal colonic mucosa cells were evaluated. The results show that P 2 O 5 promotes the formation of an apatite-like phase on the surface of Fe 2 O 3 -CaO-SiO 2 glass ceramics immersed in simulated body fluid. While TiO 2 had some adverse effect on the cell viability, P 2 O 5 had little effect on the cell viability over a certain concentration range. In this paper, the prepared Fe 2 O 3 -CaO-SiO 2 glass ceramics with P 2 O 5 added as nucleating agent are demonstrated to exhibit a good bioactivity and low cytotoxicity, which suggests good application prospects in the field of hyperthermia.