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A Detailed Study of Antimicrobial Sensitivity Pattern of Penton Valentine Leucocidin Gene Positive and Negative Staphylococcus aureus from Pus Samples
- Source :
- Proceedings of Shaikh Zayed Medical Complex Lahore. 34:24-28
- Publication Year :
- 2020
- Publisher :
- Shaikh Zayed Medical Complex Lahore, 2020.
-
Abstract
- Introduction: Staphylococcus aureus harboring Panton Valentine Leucocidin gene are emerging and spreading worldwide. PVL gene was first identified by Noel Panton and Francis Valentine in 1932 who IC Pakistan only limited data is available regarding the effect of PVL gene on sensitivity pattern of Staphylococcus aureus. Therefore, this study was conducted to understand the antimicrobial sensitivity pattern of both PVL positive and negative Staphylococcus aureus isolates. Aims & Objectives: This study was conducted to understand the antimicrobial sensitivity pattern of both PVL positive and PVL negative Staphylococcus aureus isolated from pus samples received from various indoor and outdoor departments of a tertiary care hospital of Lahore. Place and duration of study: Microbiology and Molecular Biology Laboratory Shaikh Zayed Hospital Lahore. Duration of study is one year after the approval of research topic. Material & Methods: A total of 384 Staphylococcus aureus isolates from skin and soft tissue infections were identified and selected. Their antimicrobial sensitivity testing was done by Kirby disc diffusion method using Muller Hinton agar. Results: Frequencies of PVL gene in MRSA and MSSA were 51% and 44% respectively. Frequency of PVL gene was also found to be high in Ciprofloxacin sensitive, Gentamicin sensitive, Erythromycin resistant and fusidic acid resistant isolates. Conclusion: Almost half of Staphylococcus aureus isolates were found PVL positive. They were mostly multidrug resistant. The PVL positive Staphylococcus aureus isolates showed high resistance against antibiotics than PVL negative isolates
- Subjects :
- General Computer Science
medicine.drug_class
business.industry
Fusidic acid
Antibiotics
Erythromycin
respiratory system
biochemical phenomena, metabolism, and nutrition
bacterial infections and mycoses
Antimicrobial
medicine.disease_cause
Microbiology
Multiple drug resistance
Ciprofloxacin
Staphylococcus aureus
medicine
bacteria
Gentamicin
skin and connective tissue diseases
business
medicine.drug
Subjects
Details
- ISSN :
- 2518203X and 18154905
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Proceedings of Shaikh Zayed Medical Complex Lahore
- Accession number :
- edsair.doi...........80f34dadd111e5a51480dd603f0eb4fe