Synthesis, structure and investigations of tuberculosis inhibition activities of new 4-methyl-1-substituted-1H-1,2,4-triazole-5(4H)-thione

By the reaction aminomethylation, chloromethylation and acylation of 4-methyl-4H-1,2,4-triazole-3-thiol, 4-methyl-1-substituted-1H-1,2,4-triazole-5(4H)-thione 1-8 were obtained. Molecular structure of the obtained compounds was confirmed by an elemental analysis, IR, 1H NMR and 13C NMR spectra and additionally by X-ray analysis for 2. Six new compounds 1,2,4-7 were tested for antibacterial activity against Mycobacterium smegmatis, Mycobacterium phlei and avirulent strain Mycobacterium H37Ra.