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Local acting <scp>S</scp> ticky‐trap inhibits vascular endothelial growth factor dependent pathological angiogenesis in the eye
- Source :
- EMBO Molecular Medicine. 6:604-623
- Publication Year :
- 2014
- Publisher :
- EMBO, 2014.
-
Abstract
- Current therapeutic antiangiogenic biologics used for the treatment of pathological ocular angiogenesis could have serious side effects due to their interference with normal blood vessel physiology. Here, we report the generation of novel antivascular endothelial growth factor-A (VEGF) biologics, termed VEGF “Sticky-traps,” with unique properties that allow for local inhibition of angiogenesis without detectable systemic side effects. Using genetic and pharmacological approaches, we demonstrated that Sticky-traps could locally inhibit angiogenesis to at least the same extent as the original VEGF-trap that also gains whole-body access. Sticky-traps did not cause systemic effects, as shown by uncompromised wound healing and normal tracheal vessel density. Moreover, if injected intravitreally, recombinant Sticky-trap remained localized to various regions of the eye, such as the inner-limiting membrane and ciliary body, for prolonged time periods, without gaining access either to the photoreceptors/choriocapillaris area or the circulation. These unique pharmacological characteristics of Sticky-trap could allow for safe treatment of pathological angiogenesis in patients with diabetic retinopathy and retinopathy of pre-maturity.
- Subjects :
- Pathology
medicine.medical_specialty
Angiogenesis
Neovascularization
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Ciliary body
Medicine
030304 developmental biology
0303 health sciences
business.industry
medicine.disease
3. Good health
Vascular endothelial growth factor B
Vascular endothelial growth factor
Vascular endothelial growth factor A
medicine.anatomical_structure
chemistry
030220 oncology & carcinogenesis
Cancer research
Molecular Medicine
medicine.symptom
business
Wound healing
Retinopathy
Subjects
Details
- ISSN :
- 17574684 and 17574676
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- EMBO Molecular Medicine
- Accession number :
- edsair.doi...........80840e93514323ad83791bb6f4419042