Amisulpride, Sultopride and Sulpiride: Comparison of Conformational and Physico-Chemical Properties

Amisulpride, sultopride and sulpiride (Figure 1) are antagonists of the D2-like dopamine receptors, which are members of a large family of receptors that interact with specific intracellular signalling pathways through coupling with G proteins. These compounds are substituted benzamides and present a high degree of selectivity for D2 and D3 versus D1 and D4 dopaminergic receptor subtypes. Amisulpride, sultopride and sulpiride respectively present decreasing in vitro affinities for the D2 receptor (IC50 = 27, 120 and 181 nM) and the D3 receptor (IC50 = 3.6, 4.8 and 17.5 nM).