A cationic amphiphilic peptide chaperone rescues Aβ42 aggregation and cytotoxicity

Authors :: DRGKoppalu R. Puneeth Kumar
Rahi M. Reja
Dillip K. Senapati
Manjeet Singh
Sachin A. Nalawade
Gijo George
Grace Kaul
Abdul Akhir
Sidharth Chopra
Srinivasarao Raghothama
Hosahudya N. Gopi
Source :: RSC Medicinal Chemistry. 14:332-340
Publication Year :: 2023
Publisher :: Royal Society of Chemistry (RSC), 2023.
Abstract: A cationic amphiphilic peptide effectively prevents the aggregation of soluble Aβ42 and also disintegrates matured fibrils into soluble precursors. In addition, the peptide also rescues cells from the toxicity of Aβ42.

Subjects :: Pharmacology
Organic Chemistry
Drug Discovery
Pharmaceutical Science
Molecular Medicine
Biochemistry

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