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Leishmanicidal Activity and Immunomodulatory Effect of a Mixture of Lupenone and β-Caryophyllene Oxide
- Source :
- Revista Brasileira de Farmacognosia. 31:199-206
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Evaluation of the leishmanicidal activity of different mixtures of β-caryophyllene oxide and lupenone against Old and New World Leishmania spp. showed that both the pure β-caryophyllene oxide and the 1:4 mixture of lupenone and β-caryophyllene oxide are similarly active against promastigotes of L. amazonensis, L. braziliensis, L. mexicana, L. tropica, and L. aethiopica, with IC50 values ranging from 14 to 39.3 μg/ml, and reduce the infectivity of macrophages by L. mexicana and L. tropica. However, the 1:4 mixture of lupenone and β-caryophyllene oxide showed a better selectivity index than the pure sesquiterpene and increased production of NO, H2O2, and cytokines; these results suggest that the 1:4 mixture of terpenoids has both leishmanicidal activity and an immunomodulator effect, without affecting cell viability.
- Subjects :
- Infectivity
Traditional medicine
biology
010405 organic chemistry
Chemistry
Oxide
Leishmania
biology.organism_classification
Sesquiterpene
01 natural sciences
Terpenoid
0104 chemical sciences
010404 medicinal & biomolecular chemistry
chemistry.chemical_compound
parasitic diseases
Ic50 values
Viability assay
β caryophyllene
General Pharmacology, Toxicology and Pharmaceutics
Subjects
Details
- ISSN :
- 1981528X
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Revista Brasileira de Farmacognosia
- Accession number :
- edsair.doi...........802bb503e45a9d77e3f8fd07d232696a