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Antimicrobial Peptides and How to Find Them

Authors :
Jan Münch
Ludger Ständker
Barbara Spellerberg
Rüdiger Groß
Source :
Frontiers for Young Minds. 9
Publication Year :
2021
Publisher :
Frontiers Media SA, 2021.

Abstract

Bacteria and viruses may enter our bodies through mucous membranes of the airways or the gut. To prevent infections, one defense mechanism of our immune system is antimicrobial peptides (AMPs). Most AMPs are composed of 10–50 amino acids and insert into bacterial cell membranes to destroy the cell. Some AMPs are also active against viruses and fungi. AMPs can be generated by chopping up bigger proteins like hemoglobin. The hemoglobin fragments can inactivate bacteria and viruses, while the whole hemoglobin protein cannot. To identify new AMPs, peptide libraries consisting of thousands of different peptides can be generated from human body fluids and organs. These libraries are tested for antibacterial or antiviral activity and can be further purified to identify the responsible peptide. This method may lead to the development of new antimicrobial substances with a potential for treating infections.

Details

ISSN :
22966846
Volume :
9
Database :
OpenAIRE
Journal :
Frontiers for Young Minds
Accession number :
edsair.doi...........8028613d05a900547689a5617b3b3914
Full Text :
https://doi.org/10.3389/frym.2021.567875