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Prognosis of gastric adenocarcinoma patients with various burdens of peritoneal metastases
- Source :
- Journal of Surgical Oncology. 113:29-35
- Publication Year :
- 2015
- Publisher :
- Wiley, 2015.
-
Abstract
- Background Peritoneal metastases (PM) in patients with gastric adenocarcinoma (GAC) may be identified by diagnostic laparoscopy (DL) or imaging (I). Although prognosis is poor, some patients have excellent outcome. We compared the overall survival (OS) of patients in 3 groups: those with positive cytology (CY+) by DL (DL-CY+), those with gross PM (GPM) by DL (DL-GPM+) and with GPM obvious on I (I-GPM+). Methods 146 GAC patients were identified. The Kaplan–Meier analysis, univariate, and multivariate Cox proportional hazards regression models were employed. Results Patients were primarily men (67%), with good ECOG scores (0–1; 89%), had DL (84%), had poorly differentiated GAC (92%), and had received chemotherapy (89%). The median OS for all patients was 15 months (5%CI, 12.9–18.2 months). The DL-CY+ group had median OS of 22.5 months (95%CI, 15–29.3 months). Patients with I-GPM+ had four times the risk of death than those with DL-CY+ (P
- Subjects :
- medicine.medical_specialty
Chemotherapy
business.industry
Proportional hazards model
medicine.medical_treatment
Retrospective cohort study
General Medicine
medicine.disease
Gastroenterology
Surgery
03 medical and health sciences
Peritoneal Neoplasm
Gastric adenocarcinoma
0302 clinical medicine
Oncology
030220 oncology & carcinogenesis
Internal medicine
Cytology
medicine
Adenocarcinoma
030211 gastroenterology & hepatology
In patient
business
Subjects
Details
- ISSN :
- 00224790
- Volume :
- 113
- Database :
- OpenAIRE
- Journal :
- Journal of Surgical Oncology
- Accession number :
- edsair.doi...........8027fa873b86548ae8eccc8474c5d5eb