ChemInform Abstract: Cyclocondensation of a Baylis-Hillman Adduct with Amidines

Baylis-Hillman adducts [1, 2] are polyfunctional compounds with high synthetic potential. They contain three electrophilic centers and so can react with different nucleophilic reagents including dinucleophiles to form cyclic systems. We have studied the reaction of the acetylated adduct 1 (prepared from 4-chlorobenzaldehyde and methylacrylate [3]) with the benzand acetamidines 2a,b and with S-methylisothiourea (2c).